L'skin aging it is a complex process, which occurs over the span of human life. In addition to endogenous factors, several environmental factors contribute to this process and sometimes accelerate aging. Therefore, numerous researches within the dermatological science and above all in dermato-endocrinology have the aim of developing drugs anti aging effective and one of the very promising candidates is melatonin.
Several studies have revealed that melatonin with its forte antioxidant action shows a
broad spectrum of action as a bioregulatory molecule with pluripotent and essential protective effects in many cells, tissues and other compartments of animals, humans and even plants. [147] One of the predominant properties of melatonin is its potent cyto-protective activity at both physiological and pharmacological concentrations. [147]
As for the clinical application, exogenous melatonin should be used for topically rather than orally, as this route leads to rather low blood levels due to a strong first pass effect in the liver, thus limiting access to the skin.
Topical application could be significant, since melatonin can penetrate the stratum corneum and constitute a deposit due to its particular lipophilic structure.
Thus, the endogenous production of intracutaneous melatonin, together with topically applied exogenous melatonin or its metabolites may represent one of the most potent antioxidant defense systems against UV-induced skin aging. [331-337]
Melatonin has a protective effect on oxidative stress, which are the cause of aging and skin degradation.
Abstract of the thesis "Melatonin in the plant world (Phytomelatonin): therapeutic properties and future prospects" by Dr. Giorgio Guerrini
For further information, please refer to the bibliography page.
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